Florida Atlantic and Middle Tennessee get the week rolling with a Tuesday night game in Murfreesboro. The hometown Blue Raiders are 2.5-point favorites.
On Wednesday, Louisiana Tech makes the long trip to Idaho to play Boise State. The Broncos are 22-point favorites.
Three games on Thursday. Pittsburgh is at South Florida (-13.5), Oregon State is at Utah (-11) and Memphis (-5) travels to Alabama Birmingham.
On Friday, Cincinnati (-3.5) is at Marshall and Brigham Young (28.5) plays at Utah State.
Saturday's games include Connecticut at North Carolina (-7); Auburn (-4.5) at Vanderbilt; Stanford at Notre Dame (-7.5); Missouri (-10.5) at Nebraska; Florida State at Miami (-2.5); Kentucky at Alabama (-16.5); Navy at Air Force (-6); Ohio State (-2.5) at Wisconsin and Oregon at USC (-17).